Si & C Resins

Merrifield Resins

Synonym: Chloromethyl resin
CAS Number: 9003-70-7
Molecular Formula: N/A
Merrifield resin contains thechloromethyl functional support for the synthesis of peptide acids by Boc chemistry. This resin can be attached to N-Boc Amino Acids via their cesium salts and the resulting Boc-Amino esters will treat with a mixture of TFA/DCM to obtain the free amine, which is then utilized in subsequent amide coupling/deportation/coupling sequences, thus generating the desired peptide on solid support.

Catalogue number	Mesh size	Loading ( mmol/g )
SICP 001	100-200	0.4 to 0.8
SICP 002	100-200	0.8 to 1.2
SICP 003	100-200	1.2 to 1.6

Structure

Amino methylPolystyrene Resin (AM Resin)

Synonym: AM Resin
CAS Number: 89551-24-6
Molecular Formula: N/A
Aminomethyl (AM) resin is widelyused as a core resin for acylating with carboxylic acid-containing linkers by employing the standard coupling methods of amide bond formation to lead supports for solid phase organic synthesis. It is also used in the solution phase synthesis as a scavenger to remove excess acid derivatives, alkylating agents and other electrophiles.

Catalogue number	Mesh size	Loading ( mmol/g )
SICP 004	100-200	0.4 to 0.8
SICP 005	100-200	0.8 to 1.2
SICP 006	100-200	1.2 to 1.6
SICP 007	100-200	1.6 to 2.3

Rink amide AM Resin

Synonym:Fmoc-Rink Amide AM Resin
CAS Number: 183599-10-2
Molecular Formula: N/A
Rink amide AM resin is an model support of choice to synthesis the peptide amides through solid phase peptide synthesis using Fmoc chemistry. This resin will require the removal of Fmoc protected group prior to use for coupling with amino acids. The coupling reaction can be monitored using the Kaiser test. Once the desired peptide is produced, can be cleaved it using 10% TFA in DCM.

Catalogue number	Mesh size	Loading ( mmol/g )
SICP 008	100-200	0.3 to 0.6
SICP 009	100-200	0.6 to 0.8
SICP 010	100-200	0.8 to 1.0

Structure

MBHA Resin

Synonym: 4-Methylbenzhydrylamine
CAS Number: N/A
Molecular Formula: N/A
MBHA (4-methylbenzhydrylamine) resin is used as a solid support for the synthesis of carboxamides or C-terminal peptide amides by Boc chemistry. The resin can be cleaved from the product by HF and it is stable towards TFA conditions.

Catalogue number	Mesh size	Loading ( mmol/g )
SICP 011	100-200	0.3 to 0.6
SICP 0012	100-200	0.6 to 0.8
SICP 0013	100-200	1.0 to 1.2

Rinkamide MBHA Resin

Synonym: Fmoc-Rink amide MBHA resin;
CAS Number: 431041-83-7
Molecular Formula: N/A
Fmoc-Rinkamide MBHA resin, This support comprises the modified rink amide linker attached via norleucine to MBHA resin. And is an ideal tool for the SPPS of peptide amides. Cleavage from this can be affected by a single step of treatment with 95% TFA, Providing peptide amides in high yields and purities.

Catalogue number	Particle size (Mesh)	Loading ( mmol/g )
SICP 0014	100-200	0.3 to 0.6
SICP 0015	100-200	0.6 to 0.8

Structure

2-Chlorotrityl Chloride Resin

Structure

2-Chlorotrityl Chloride Resin

Synonym:2-CTC Resin
CAS Number: 42074-68-0
Molecular Formula: N/A
2-Chlorotrityl Chloride (CTC) resin is commonly used to prepare the C-terminal acid peptides in the solid phase organic synthesis. This is extremely an acid-labile resin and can be cleaved under very mild acid conditions without reacting with side chain functional groups like Boc/tBu, Trt/Acm etc. Thus, it can also be used to prepare protected peptide sequences and obtained the same through the cleavage from this matrix by treatment with AcOH/TFE/DCM,0.5% TFA or HFIP. 95% TFA will be used to cleave the resin to obtain the fully deprotected peptide fragments.

Catalogue number	Mesh size	Loading ( mmol/g )
SICP 016	100-200	0.5 to 0.8
SICP 017	100-200	0.8 to 1.2
SICP 018	100-200	1.2 to 1.6

Wang Resin

Synonym: : 4-Benzyloxybenzyl Alcohol Resin
CAS Number: 65307-53-1
Molecular Formula: N/A
Su-Sun Wang in 1973 reported the most popular solid-phase linker is the Wang linker (4-hydroxybenzyl alcohol), usually referred to as the Wang resin. Commonly used as a solid phase support to accomplish the C-terminal peptide acid. The resin can be readily cleaved by moderate treatment with trifluoroacetic acid.

Catalogue number	Mesh size	Loading ( mmol/g )
SICP 019	100-200	0.3 to 0.5
SICP 0020	100-200	0.6 to 0.8
SICP 0021	100-200	0.9 to 1.1

Structure

FMP Resin

Synonym: (4-Formyl-3-methoxyphenoxymethyl)polystyrene resin
CAS Number: N/A
Molecular Formula: N/A
FMP Resin is used for the synthesis of high quality azides, which could be used for direct “click assembly” and in situ screening of enzyme inhibitors.

Catalogue number	Mesh size	Loading ( mmol/g )
SICP 022	100-200	0.8 to 1.0

Preloaded Resins (or) Amino acid loaded Resins

Catalogue number	Preloaded resins	Mesh size	Loading ( mmol/g )
SICP 023	Fmoc-Gly-Wang Resin	100-200	0.3 to 0.6
SICP 024	Fmoc-Tyr(tBu)-Wang Resin	100-200	0.3 to 0.6
SICP 025	Fmoc-Gly-Rinkamide AM Resin	100-200	0.3 to 0.6
SICP 026	Fmoc-Pro-Rinkamide AM	100-200	0.3 to 0.6
SICP 027	Fmoc-Ser-Rinkamide AM Resin	100-200	0.3 to 0.6
SICP 028	Fmoc-Pro-2-CT Resin	100-200	0.3 to 0.6
SICP 029	Fmoc-Gly-2-CT Resin	100-200	0.8 to 1.0
SICP 030	Fmoc-Thr(tBu)-OL-2-CT Resin	100-200	0.6 to 0.8
SICP 031	Fmoc-Cys(trt)-2-CT Resin	100-200	0.6 to 0.8
SICP 032	Boc-Pro-Merrifield Resin	100-200	0.8 to 1.0

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Resins For Peptide Synthesis

Structure

Structure

Rink amide AM Resin

Structure

Structure

Structure

2-Chlorotrityl Chloride Resin

Structure

2-Chlorotrityl Chloride Resin

Structure

Structure

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